I'm running GameEx with Windows 10 on the last preview build. The only problem I'm having is with the Fusion emulator and that was quite a few preview builds ago. I need to check it again. MAME, Visual Boy Advance, Nestopia, SNES9X, and Stella are all working fine. As are my Xbox 360 wireless controllers and IPAC2 based control panel. My system is pretty low power and inexpensive (Athlon 5350, Asrock AM1H-ITX, 12 GB ram, cheapie SanDisk SSD). Win 10 runs a bit smoother than 7 did. That's a big reason why I'm making the jump.