To get per game setups load the emulator, add your ISO location to it, right click your game, go to properties and voila. BTW Dolphin has been on their Sh** lately and have made tons of improvements and the compatibility is super high with no setting modifications and I highly recommend you update to the latest dev build you can find on their website. I say this because I have a LOT of GameCube and Wii goin on with my rig and I really never have to adjust any settings for any game except for like 3 (Need for Speed Underground 1,2, and Star Wars Rouge Squadron 2). Doesn't bother me much though because I have a real Wii right next to my PC for games that can't be emulated well. As far as the GPU/Controller setups. Again, I have never had to mess with those.But I also have x360 controllers and the Dolphin Bar for real Wiimote playability. If you don't have any 360 controllers or the Dolphin Bar I highly recommend those too. Very worth it. Also dependent on your Graphics Card you'll want to carefully choose your in game renderer. I stick with Direct3D because it seems to be the fastest renderer to me. It may be different with yours. You can also mess with your dolphins settings through the .ini and make even more changes I think you otherwise can't though the GUI.