You definately should have Mame.ini in E:\Mame not in E:\Mame\Ini. I don't even look in any folder other than Mame's root folder for Mame.ini, so leave it in root that's were it should be. Secondly, this new PC, it is a stripped down version of XP or something? It looks like it can't find the Speech components. You need to install sapi51.msi and sapi51xp.msi. Hopefully that should get it running.