This is obviously a problem with the code that needs fixing. My personal opinion (not Tom's), is that the GameEx code needs to address this issue. Anything we come up with in this thread to "fix" the resultant symptoms is not a "solution", it's a hack to make things work. I was interested in helping make it work in the mean time, but I was hoping Tom might see the thread and step in with a suggestion. Anyway, I don't really have any idea what would keep the mouse from working on the desktop. I'm not even sure what to search the registry for in this case. Sorry, I've got nothing... EDIT: After sleeping on it, I realized that it's still possible that both of these systems have the same issue due to a setup problem. I still have no clue what could be wrong, but just because two systems have the same problem doesn't mean that it's the core code, it could still be either the way you have GameEx set up or an outside application causing this. Perhaps you both could post a log when this happens. I know you said it doesn't always happen, but if it's a problem with GameEx, then it would have to be determined what's going on to cause this. If it's an outside app conflicting with HideOS, then you might want to think about what else you have running at the time. Again, I really don't know. That's my best suggestions though. Good luck!