Yes it is possible. Simply remap the "i" key to "ESCAPE" in the GameEx Advanced Config Editor app by headkaze by doing the following... Click on the General tab. Click on Enabled which will enable this config for use in GameEx. Click on Map Escape which will close the emulator process if ESCAPE is pressed. Click on Keyboard ReMap tab. Click on Enabled to enable in GameEx. Triple click on From Key and a dialog will popup asking to Press a key so there put "i". Triple click on To Key and same dialog will pop up and press "ESCAPE". Click File and Save As... (Save as your desired file name). Now in GameEx setup, click the drop down Advanced Config and select your saved config for use. Now when you press your "i" key then it will send "ESCAPE" to that emulator and close it's process. There's other settings in there that might need some tweaking but play around with that to get your desired results. That should give you something to start with. Let us know how that works out for you. There are other solutions to accomplish this but this is the most simple way and not having to use 3rd part apps to accomplish same effect.