This was last discussed here. From my experience, Magic Engine only liked cue files which wasn't supported by VirtualCloneDrive. So using it won't work. Daemon Tools is the solution. Here's my config for reference. [Emulator_25] Enabled=True STARTPAGENAME=[Console] NEC TurboGrafx CD (MagicEngine) TITLETEXT=NEC TurboGrafx CD StartPageLogo=[Console] NEC TurboGrafx CD ROMFilter=*.cue RomPath=D:\Emulation\Roms\Other\NEC - TurboGrafx-CD RomsInFolders= SnapPath= TitlePath= BoxPath= CartPath= ManualPath= ControlPanelPath= InstructionsPath= WorkingPath=C:\Emulators\MagicEngine MapKeys=True WaitBeforeKeys= SendKeys= ReplaceDash=False ReplaceUnder=False Capitals=False RemoveBrackets=False ShowDesktop=True Debug=False MAPFile=D:\Emulation\Roms\Other\NEC - TurboGrafx-CD\[Console]NEC -TurboGrafx-CD.map AlsoLaunch= Command=pce.exe "syscard3.pce" LaunchBefore=""C:\Program Files\DAEMON Tools Lite\daemon.exe" -mount 0,"[ROMPATH]\[ROM]\[ROMFILE]"" LaunchAfter="C:\Program Files\DAEMON Tools Lite\daemon.exe" -unmount 0 configFile= ExcludedFiles= CustomBackground= PlayMusic=False DontShowInfo= PlaySelectionMusic=False SelectionMusicFolder= PCGame=False DATABASE= UseDbName= GamesIn7Zips=False PlayInScreenSaver=False ShowMostPlayed=True RandomMostPlayed=True CDCheck=False CDCheckFile= CustomArtName1= CustomArtPath1= CustomArtName2= CustomArtPath2= CustomArtName3= CustomArtPath3= [GENERAL] DumbyValue= Note that depending on your setup then your options might be different for Daemon Tools. Let us know if you need further assistance.