While I have never had gameex issues with spybot but I did have issues with spybot and pc games as in when I had spybot installed pc games would crash,freeze,and sometimes shut off the monitor.I think it had something to do with its real time protection,lucky for me I hadnt installed any other new software around that time so i was able to pinpoint SB as the culprit early. on a side not,about 6 months ago I switched to windows defender and I have to say it is doing a fine job,that with avast free antivirus,(I switched from a paid version of mcafee after it flagged SVCHOST.exe and quarentined it) and comodo firewall and I have been virus/malware free