It sorta feels like everytime someone tries to help, you question the authenticity or complain about the questions and requests from the assistor. I really think it's probably a language thing and I apologize if it is, but your comments read as really abrasive. You won't get much help from anyone here if you're going to serve them a spoonful of bleach every time someone responds.
That being said... Truth is, it matters how you play, which is why @Draco1962 asked that question. Different inputs use different methods... Some are Direct Input, some are X Input, some are keyboard strokes emulated through buttons... Each thing matters, no matter how insignificant it seems to you.
/me climbs off soapbox
Now for your post... I'm having a tough time understanding what you're asking. Is the issue that ESC closes your PC game and you don't want it to? If so, I assure you it's the global mapping that's getting in your way:
You need to disable this setting, otherwise you will always have ESC act as an exit key. You will then need to do something in the emulator itself instead. By definition, "global exit" means exactly that, it's global acrossed everything. There may be a way to ignore it for an emulator, but I don't use/need the global exit feature. I use Xpadder key mapping/assignments instead.
If what you're saying is that you can't get it to close using ESC but that's what the PC requires and you're using a gamepad... You can try this setting:
Alternately (since I know you're already using Xpadder based on the last thread(s) I assisted you with), map a key to it and load a profile for your PC games. I have a few emulators that only have a few non-essential keys mapped (specifically for RetroArch, I have a SHIFT key I hold to load an alternate button set, and that modifier has things like Rewind, Save/Load State, Emulator Exit, etc). I've never had much luck with that baked-in Advanced Config feature you're asking about personally, so I don't use it.
Hopefully some of that is helpful.