When I run epsxe everything works fine and the rompath parameter is just right: chcp 65001 E: CD "E:\GameEx Data\Emulators\ePSXe" ePSXe.exe -nogui -loadbin "E:\GameEx Data\Roms\Sony Playstation\Roms\Action Bass.cue" Also, Mame, Dreamcast (nulldc) and 3Do (4do) are working. I just found something very unusual in my Run Last Game.ini .. I loaded a dreamcast game, it worked fine, but then I tried to load a sega genesis game after that .. it didn't work and the Run Last Game.ini was: chcp 65001 E: CD "E:\GameEx Data\Emulators\Fusion" Fusion.exe -gen -fullscreen "E:\GameEx Data\Roms\Sega Dreamcast\Roms\Airforce Delta v1.000 (1999)(Konami)(NTSC)(US)[!][1S T-9501NAF]\3 Ninjas Kick Back.gen" It seems that Gameex cached the last rompath, I really don't know what's going on .. everything worked before the update!!!