ok. I know Tom and others said to disable Touch Screen. I for the life of me thought I disabled it but I guess when I did the fresh install it got checked again. Now that I have disabled Touch Screen on both Dell Windows 10/MacBook Pro with Parallels 15 with Windows 10 ver 2004. That was the fix. Once I disabled it and everything worked on both stations. I must say the only problem is still with Parallels 15 it assigns an external drive to a new location almost every-time. So I just added X, V, Y to the roms list location and now so no matter what drive letter it assigns it will be mapped in Setup Wizard.
I am so glad I purchased this platform vs others. It has so many options/features and blow the others out of the water.
So to wrap it up all is solved and fixed: Moved GameEx to C drive, Disabled Touch Screen, Added extra drive locations so if it assigns my external drive to any letter it will find them.