Just downloaded today's latest update. It would not run at all. Double-clicked the GameEx and it would not start. Tried even a clean install and and replaced gameex.ini with my recent backup. Still no joy. Reinstalled the last version before this one. Up and running again.
Windows 10, 64bit fresh system with lava filters, etc. Did check for stalled processes and rebooted. Couldn't get the newest version to launch.