Yeah. You're using the wrong build of Gens. I was using the wrong build of ZSNES and it kept failing on me, over and over. I downloaded the latest version from zsnes.com and that fixed my problem. (GameEx automatically downloaded the older version...) So, if you haven't already, switch. You won't get a nosebleed, I promise. FWIW it's really easy to use Fusion. It took me literally 2 minutes to get it to work with GameEx. If you INSIST on keeping the same emulator, I recommend making sure your settings in Gens ensure that the emulator loads in fullscreen mode.