I managed to the MAME keys lighting up, but I'm still having issues with the plugin configuration program. I'll load it up, hit the Profile Editor tab, click Dreamcast, click Ikaruga, make some changes (changing Always Active to False for a few buttons), click Save, click Exit, then go back in and my changes were never saved. In some cases I've reverted to editing ini files, but this is far from desirable Edit: This time it worked? Maybe it's related to me remote desktopping it (seems to save changes OK) vs editing via the machine itself. Regardless, can anyone explain the difference between "State" and "Always active"?