Back again to come to the gods of good advice and all knowledge. Desmume working perfectly when launch outside of GameEx. When Launch from GameEx, stuttery performance - kinda like laggy or something maxing out. However, monitored CPU+RAM+GPU - all waaay below maxing out. Screenshot (blurgh - wish their was a way to resize images on this board): Running without any plugins (disabled GameInfo) and emu settings look kosha. There is an AHK script running in bg, but desmume works fine when this script is running without gameex. Puzzled! Feels like there's something interfering between GameEx + Desmume. Why can't applications just get along!? Ini attached. Anyone any ideas? Thanks Nintendo DS.ini