Just tried this on my 4k setup as well. Same crash.
20:02:43.2 2/5/2018: PinballX - Version 2.50
20:02:43.3 2/5/2018: Windows 10 Pro 64-bit (31.8GB)
20:02:43.3 2/5/2018: Loading Settings
20:02:43.3 2/5/2018: Initialize Component
20:02:43.3 2/5/2018: Initialize Display
20:02:44.4 2/5/2018: Loading PlugIns
20:02:44.4 2/5/2018: Loaded Plugin:"DirectOutput PinballX Plugin" Version 1 By Swisslizard
20:02:46.3 2/5/2018: PlugIn: "DirectOutput PinballX Plugin" Initialized OK
20:02:46.3 2/5/2018: Using Plugin System Version: 1
20:02:46.4 2/5/2018: Created DirectX BackGlass Window
20:02:46.5 2/5/2018: Created DirectX DMD Window
20:02:46.7 2/5/2018: Hiding Cursor
20:02:46.7 2/5/2018: Hiding Taskbar
20:02:46.7 2/5/2018: CPU: Intel(R) Core(TM) i7-5820K CPU @ 3.30GHz
20:02:46.7 2/5/2018: GPU 1: NVIDIA GeForce GTX 1080
20:02:46.7 2/5/2018: Displays: 3
20:02:46.7 2/5/2018: Load Game List
20:02:46.8 2/5/2018: Loading Database: Pinball FX2
20:02:46.8 2/5/2018: Loading Database: Pinball FX3
20:02:46.8 2/5/2018: Loading Database: Visual Pinball
20:02:46.8 2/5/2018: Finding and matching artwork and videos
20:02:46.9 2/5/2018: Loading Game Statistics and Scores
20:02:47.5 2/5/2018: Main display running full screen windowed.
20:02:47.6 2/5/2018: Loading Surfaces
20:02:47.8 2/5/2018: Finished Loading Surfaces
20:02:47.9 2/5/2018: Initialize Audio
20:02:47.9 2/5/2018: Set Keyboard Controls
20:02:47.9 2/5/2018: Initialize Joystick
20:02:47.10 2/5/2018: 1 Joystick Attached
20:02:47.10 2/5/2018: Started
20:03:00.7 2/5/2018: Error. Exiting
20:03:00.7 2/5/2018: Parameter is not valid.
20:03:00.7 2/5/2018: at System.Drawing.Bitmap..ctor(Int32 width, Int32 height, PixelFormat format)
20:03:00.7 2/5/2018: at System.Drawing.Bitmap..ctor(Int32 width, Int32 height)
20:03:00.7 2/5/2018: at Direct2D.Direct2d.Surface.a(Bitmap& A_0, Device& A_1)
20:03:00.8 2/5/2018: at Direct2D.Direct2d.Surface..ctor(Bitmap Image, Device Device)
20:03:00.8 2/5/2018: at PinballX.FrmMain.d(Boolean A_0)
20:03:00.8 2/5/2018: at PinballX.FrmMain.u()
20:03:00.8 2/5/2018: at PinballX.FrmMain.ap()
20:03:00.8 2/5/2018: at PinballX.FrmMain..ctor()
20:03:00.9 2/5/2018: Disposing Plugins
20:03:00.9 2/5/2018: Showing Taskbar
20:03:00.9 2/5/2018: Unhiding Mouse Cursor
20:03:00.10 2/5/2018: Bye